Esmaeil has a Master's Degree in Electrical Engineering from the Sharif University of Technology, Iran, and a PhD in Electrical Engineering and Control System Theory from Aalborg University, Denmark. He has previously worked as a visiting professor at the School of Engineering and Applied Sciences (SEAS) at Harvard University, and is now a professor of artificial intelligence and clinical machine learning at the Maersk Mc-Kinney Moller Institute, University of Southern Denmark. At the university, he is also Head of the Applied AI and Data Science section.
Esmaeil is the only Danish member of the editorial board of Nature Digital Medicine and thus represents Danish research and approach to healthcare and digital medicine in a global context.
His primary research interests include artificial intelligence, clinical machine learning, non-invasive medical robots as well as green and renewable energy. He aims to use his research to improve patients' health and welfare through better medicial solutions based on predictive clinical algorithms, support tools and medical robots. Esmaeil also aims to help protect the environment through the optimisation of green energy production generated from renewable resources such as wind turbines and fusion energy.